Two types of diabetes are usually seen in patients with cirrhosis: type 2 diabetes mellitus and hepatogenous diabetes (HD). The HD is an. Download Citation on ResearchGate | Hepatogenous diabetes: Pathophysiology, therapeutic options and prognosis | About 80% of patients with chronic liver. A literature search was conducted in different databases to study the topic of liver problems and diabetes. The aim of the study was to explore more about an.

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Liver cirrhosis and diabetes: February 22, P- Reviewer: Diabetes and Liver an Association: Contribution of reduced insulin sensitivity and secretion to the pathogenesis of hepatogenous diabetes: However, the association of liver cancer with diabetes hepatogenouus dubious due to mix findings and conflicting results of some studies. Insulin resistance in cirrhosis: How to cite this article: Metabolic syndrome after liver transplantation: There was a reduction in hepatic glycogen in acute diabetes during fasting but increased in chronic diabetes.

Diabstes article has been cited by other articles in PMC. They also highlight the lack of research on long-term treatment of diabetes and the lack of treatment recommendations for these vulnerable patients. Hepatogenous Diabetes Mechanism and Some Evidences.

A suggestive correlation between marked increases of lipids and hepatomegaly was seen among the diabetes patients [ 9 ]. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Thus, the study concluded that Gallic acid has a protective effect against oxidative stress-induced damage in the diabetic state [ 49 ]. Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals. Based on the above-discussed evidences, HD should be considered as a complication of CLD in the same way as hepatic encephalopathy, ascites, portal hypertension or hepatorenal syndrome.


As a result, insulin clearance is impaired, hence leading to peripheral insulin resistance though down-regulation of insulin receptors. It is unclear how diabetes influences hepatocarcinogenesis.

Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?

In addition, the described differences between hereditary type 2 DM and HD regarding pathophysiology, risk factors, clinical features, effects on outcome and therapeutic results are strong reasons for diagnosing them as separated entities. Diabetes mellitus heightens the risk of hepatocellular carcinoma except in patients with hepatitis C cirrhosis. In addition, the impact of glucose control on clinical outcomes of patients has not been evaluated. In the other side, pre-transplant DM is a risk factor for the development of diabetes after transplant[ 34 ].

Hence, there is a great chance, that the future studies will broaden hepatogenouss knowledge about gepatogenous question marks linked with this association. Some surprising findings were shown by La Vechia et al.

Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?

Clin Gastroenterol Hepatol ;3: Hepatogenous diabetes in cirrhosis is related to portal pressure and variceal hemorrhage. The former one is frequently associated to metabolic syndrome that gives rise to non-alcoholic fatty liver disease, liver cirrhosis and hepatocellular carcinoma HCC. The published hepaotgenous is sufficient to show that there is a possible association between the two. Patients suffering from this condition have low frequency of risk factors of type 2 DM.


Nevertheless, there was a high heterogeneity among studies included in the analysis and post-hoc analysis of randomized controlled trial did not reveal significant association between antidiabetic medications use and the risk of HCC[ 51 ].

As liver disease progresses, diabetes becomes clinically manifested, therefore diabetea HD may be considered as a marker of liver function deterioration[ 22 ]. Hence, developing diabetes [ 1415 ]. Please review our privacy policy. Non-alcoholic fatty liver disease and insulin resistance: Is it a class effect?

Ferrannini E, Solini A. This paper will review current concepts in relation to the pathopysiology, the impact on the clinical outcome of cirrhosis, and the therapy of HD. The liver glycogen during post prandial and post hour fast state was calculated in streptozotocin STZ -diabetic rats by Ferranini et al.


Hepatogenous diabetes: Is it time to separate it from type 2 diabetes?

November 28, Citation: It associates with increased rate of liver complications and hepatocellular carcinoma, and decreased 5-year survival rate. Finally, genetic factors rather than only liver or pancreatic damage may also be involved in the susceptibility to develop HD as it was shown in a recent study with patients with liver cirrhosis of diverse etiology.

It can make the management of such patient difficult if the clinician is not aware that there is an association of hepatohenous with liver. We have discussed some liver alterations caused by hepatogenoue, or some liver problems prevalent in diabetic patients.