Rotate the site of injection to avoid irritation or sterile abscess formation with repeat administration. Intramuscular Depot injection (fluphenazine decanoate or . PACKAGE LEAFLET: INFORMATION FOR THE USER. Modecate® 25mg/ml Injection fluphenazine decanoate. Is this leaflet hard to see or read? Phone . ADMINISTRATION). Fluphenazine decanoate is not indicated for the management of severely agitated psychotic patients or psychoneurotic.

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Fluconazole xecanoate been associated with QT prolongation and rare cases of TdP. Mostly excreted in urine via the kidneys; some is excreted in feces via the biliary tract.

Consider ECG monitoring if fluphenazine must be used with or after artemether; lumefantrine treatment. Granisetron has been associated with QT prolongation. Fluphenazine is associated with a possible risk for QT prolongation. Extrapyramidal reactions are not uncommon, but fluphenazine does not have marked sedative or hypotensive properties.

In addition, cabergoline, a dopamine agonist, can diminish the effectiveness of dopamine antagonists such as the phenothiazines.

Major Use of medications that lower the seizure threshold should be carefully evaluated when considering the use of intrathecal radiopaque contrast agents. Moderate Because it also blocks central dopamine receptors, metyrosine should be avoided or used cautiously in patients receiving a phenothiazine to minimize the risk of additive adverse CNS effects. Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: Carbamazepine is a potent inducer of the cytochrome P hepatic oxidase system, and can reduce plasma concentrations of the phenothiazines.

fluphenazine decanoate

In addition, fluphenazine is associated with a possible risk of QT prolongation; therefore, cardiac effects are possible.

Fluphenazine is contraindicated in patients with hematological disease.

packae However, studies to date have not shown an association between chronic administration of these drugs and human mammary tumours. Minor Both fluphenazine and ciprofloxacin are associated with a possible risk for QT prolongation; therefore, caution is advised when administering these medications concurrently. Reporting of suspected adverse reactions. May result in hypotension.


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In Aprildecsnoate FDA mandated that all manufacturers of atypical antipsychotics e. Minor Consider periodic monitoring of EGCs for QT prolongation and monitor electrolytes if coadministration of histrelin and fluphenazine is necessary; correct any electrolyte abnormalities. Phenothiazines inhibit glucose uptake into cells, and hence may affect the interpretation of PET studies using labelled glucose. However, some patients may require treatment despite the presence of the syndrome.

CNS depressants decaniate potentiate the effects of cannabidiol. Droperidol may also cause increased CNS sedation when given with flurphenazine.

Moderate Additive effects may be seen when phenothiazines are used concomitantly with other drugs with antimuscarinic activity, such as brompheniramine, a sedating H1-blocker.

Moderate Phenothiazines can potentiate the CNS-depressant action of other drugs such as skeletal muscle relaxants. Increases plasma levels and toxicity. The hazard of hyperpyrexia may be increased by especially hot or humid weather, or by drugs such as anti-parkinsonian agents, which impair sweating.

Modecate Injection 25mg/ml

If coadministration occurs, closely monitor patients for seizure activity. Avoid spilling the solution on the skin and clothing. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the initiation of antipsychotic treatment, which patients are likely to develop the syndrome.

Major Phenothiazines, especially in large quantities, can cause a dystonic reaction. Patients without previous exposure to a depot fluphenazine formulation: Additionally, sleep-related behaviors, such as sleep-driving, are more likely to occur during concurrent use of hypnotics and other CNS depressants than with use of a hypnotic alone.

Caution should be exercised during simultaneous use of these agents due to potential for additive hypotension and excessive CNS effects sedation and dizzinesswhich can impair the ability to undertake tasks requiring mental alertness.


Halofantrine should be avoided in patients receiving drugs which may induce QT prolongation, such as phenothiazines.

Refer to the OBRA devanoate for complete information. According to the manufacturer, since iloperidone may prolong the QT interval, it should not be used with other agents also known to have this effect, such as fluphenazine. The effect of abarelix on the QT interval may be due to androgen deprivation or other variables, as similar effects were seen in men that received a gonadotropin-releasing hormone GnRH agonist with a nonsteroidal antiandrogen.

Concurrent use fluphenxzine phenothiazines and cocaine may increase the risk of acute dystonia. Major COMT inhibitors should be given cautiously with other agents that cause CNS depression, including phenothiazines, due to the possibility of additive sedation.

Moderate Phenothiazines can potentiate the CNS-depressant action of other drugs such as dichloralphenazone. While Modecate injection has been shown to be effective in acute states, it is particularly useful in the maintenance treatment of chronic patients who are unreliable at taking their oral medication, and also of those who do not absorb their oral phenothiazine adequately.

Regulate body temperature as needed. An antipsychotic should generally be used only for the conditions listed in the guidelines e. Also, concomitant use may increase the risk for phototoxicity.

Severe Patients receiving other drugs which have fouphenazine potential for QT prolongation, such as phenothiazines, have an increased risk of developing proarrhythmias during bepridil therapy.