”serotonin-fatigue hypothesis” is clear, several seemingly well-conducted studies have failed to . brain neurotransmitter systems (Meeusen and De Meirleir. Brain neurotransmitters in fatigue and overtraining. Romain Meeusen,ab Philip Watson,b Hiroshi Hasegawa,ac Bart Roelands,a Maria F. Such a change in neurotransmission has a direct impact on fatigue. sudden and profound central fatigue in athletes due to overtraining involves hypothalamic . These parts of the brain are also critical for evaluating and regulating external.

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Inadequate recovery from vigorous exercise.

Brain neurotransmitters in fatigue and overtraining.

This is not the only neurotransmitter associated to the perception and development of the fatigue, but it is the one that is under study This form of overtraining is easy to be diagnosed, since the athlete feels sick, and there are several indicator signs and symptoms, such as: Impact of reduced training on performance in endurance athletes.

Am J Clin Nutr ; Serotonin could even to increase the anxiety, acting on the tonsils in order to restrain the panic, acting on the PGM Even so, there are concrete evidences of the important role of the serotonin in the performance during prolonged exercises Proc Nutr Soc ; All the authors declared there is not any potential conflict of interests regarding this article.

However, whenever it is detected a discrepancy between what is jn and what happened, the septo-hippocampal system starts in generating an inhibition of the behavior, an increasing vigilance level, driving the individual’s attention to possible neurogransmitters of danger.

Amino acid metabolism, branched chain amino acid feeding and brain monoamine function. Stress can be defined within a psychological perspective as the individual perception related to the imbalance between the physical or psychological demands, and their resources to face them in an activity that is regarded important, such as, for instance, the sportive action to overtrsining athlete 8. Effects of athletic endurance training on infection rates and immunity. In terms of training, the overreaching causes a temporary decrease in the body’s functioning, followed by an adaptation that overpasses the initial level of such functioning.


When prolonged and excessive training happens, concurrent with other stressors and insufficient recovery, performance decrements can result in chronic maladaptations that can lead to the overtraining syndrome OTS.

It is possible that the energetic metabolism, which is secondary to the endocrine changes, be changed in the overtraining syndrome, and thus, consequently affecting the fatigue as well. Braz J Med Biol Res ; Nutritional aspects of exercise-induced fatigue.

Brain neurotransmitters in fatigue and overtraining.

Urhausen A, Kindermann W. Hartmann U, Mester J.

Several works in the Physiology area defines the term fatigue as “incapacity to maintain the power outcome” both in resistance exercises and in the overtraining states 10,20, Rossi L, Tirapegui J. Proc Nutr Soc ; It is quite common that athletes and non-athletes exceed the limits of their physical and psychological capacities causing the development of the overtraining syndrome, which is defined as the neuroendocrine disorder hypothalamohypophysialresulting from the imbalance between the demand of the exercise and the possibility of assimilation of the training, causing metabolic changes with consequences comprising not only the performance, but also other physiological and emotional aspects.

Therefore, proteins, carbohydrates, and fat, which are the major constituents of the diet, act not only as energetic bgain, but also as precursors of several neuroactive substances.

Primarily observed in athletes, the overtraining syndrome is characterized by metabolic changes, reduction in the athletic performance, and the response to the training in healthy individuals, incidence of bruises and viral xnd bacterial infections due to the fall in the immunological resistance, alterations in the mood, constant overtraihing, etc. As brain function appears to be dependent upon the interaction of a number of systems, it is unlikely that a single neurotransmitter system is responsible for central fatigue.


The resting athlete may present no symptoms, but these symptoms can supervene neurotransmifters a furtive and sudden way. Blackwell Scientific Publications, ;1: Psychology neurotranssmitters sport injury. Aiming to understand such mechanism, this reviewing work has the purpose to analyze those factors that synergistically contribute to the outcome and maintenance of the signs, symptoms, and imbalances that characterize it.

Carbohydrates, branched-chain amino acids, and endurance: Decreased nocturnal catecholamine excretion: Evidence for possible role of 5-hydroxytryptamine in the genesis of fatigue in man: Serotonin and the biology of feeding.

Relationship of the overtraining syndrome with stress, fatigue, and serotonin

The development of the overtraining syndrome involves several internal biological and external environmental factors that must be identified and controlled in order to avoid it is settled down.

Drix A, et al. The Physician and Sportmedicine ; Several days of intentionally heavy training are followed by a lighter training and resting for a few days, in order to reach the super-compensation and the performance climax. Hormonal responses of elite swimmers to overtraining. The parasympathicotonic originated syndrome is characterized by predominant inhibition processes, physical weakness, and lack of motor activity. Studies indicate that the sensitivity changes, or low regulation of the central and peripheral serotonin receptors are associated to the fatigue during prolonged exercises 19and to the body adaptation in the resistance training Eur J Clin Nutr ; The term stress means the status generated by the perception of the stimulus that cause emotional excitement, and upon the perturbation of the homeostasis, it triggers an adaptation process that is characterized among other changes by an increasing adrenaline secretion, producing several systemic manifestations with physiological and psychological disturbances