Eur J Pediatr. Aug;(8) Epub Jun 4. Periventricular leucomalacia: a review. Blumenthal I(1). Author information: (1)The Royal Oldham. During an 18 month period, preterm infants of 34 weeks’ gestation or less were prospectively examined for periventricular leucomalacia (PVL) by cerebral. Periventricular leucomalacia is the term used to describe cerebral infarctions occurring near the lateral ventricles in neonates. The lesion was first described by.

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Case 6 Case 6. Periventricular leucomalacia is a condition that causes lifelong disability and considerable economic burden.

Periventricular leucomalacia and neurodevelopmental outcome in preterm infants.

Avoiding premature birth allows the fetus to develop further, strengthening the systems affected during the development of PVL. All treatments administered are in response to secondary pathologies that develop as a consequence of periventriculzr PVL.

It is thought that other factors might lead to PVL, and researchers are studying other potential pathways. Pneumopericardium Persistent fetal circulation. Two major factors appear to be involved in the development of PVL: About Blog Go ad-free. The link between the two is not entirely clear; however, it appears that both genetic and early environmental factors are involved. Correlation of ultrasound, clinical, and nuclear magnetic resonance functions.

A rat model that has white matter lesions and experiences seizures has been developed, as well as other rodents used in the study of PVL. Case 3 Case 3. Edit article Share article View revision history. Journal List Arch Dis Child v. Additionally, treatment of infection with steroids especially in the 24—34 weeks of gestation perievntricular been indicated in decreasing the risk of PVL. Although no treatments have been approved for use in human PVL patients, a significant amount of research is occurring in developing treatments for protection of the nervous system.


Cranial ultrasound provides a convenient, non-invasive, relatively low-cost screening examination of the haemodynamically-unstable neonate at the bedside.

Please refer to the article on patterns of neonatal hypoxic—ischemic brain injury for a relation between perinatal brain maturation process and these lesions. A relation between size and site of the lesion and type and severity of the handicap was established. Ileus Necrotizing enterocolitis Meconium peritonitis.

Typically, some abnormal neurological signs such as those previously mentioned periventricula visible by the third trimester of pregnancy 28 to 40 weeks after conceptionand definitive signs of cerebral palsy are visible by six to nine months of age. Those generally considered to be at greatest risk for PVL are premature, very low birth-weight infants.

Periventricular leukomalacia | Radiology Reference Article |

Tumanov [3] in published the world’s first monograph devoted to PVL. Because white matter injury in the periventricular region can result in a variety of deficits, neurologists must closely monitor infants diagnosed with PVL in order to determine the severity and extent of their conditions.

Patients are typically treated with an individualized treatment. Researchers have begun to examine the potential of synthetic neuroprotection to minimize the amount of lesioning in patients exposed to ischemic conditions. Journal of Child Neurology. MRI T2 Case 1: Archives of Disease in Childhood.


Children and adults may be quadriplegicexhibiting a loss of function or paralysis of all four limbs. These hypoxic-ischemic incidents can cause damage to the blood brain barrier BBBa system of endothelial cells and glial cells that regulates the flow of nutrients to the brain. Risk factors in the development of intraventricular haemorrhage in the preterm neonate. Case 8 Case 8. An emphasis on prenatal health and regular medical examinations of the mother can also notably decrease the risk of PVL.

Progressive necrosis of the periventricular tissue with resulting enlargement of the ventricles is called end-stage PVL.

Periventricular leukomalacia – Wikipedia

MRI T1 Case peucomalacia It is an ischaemia reperfusion injury of the white matter, free radicals being the final pathway to pre-oligodendrocyte destruction and impaired myelination.

In the process of morphogenesis focuses PVL pass through three stages: Central Nervous SystemPaediatrics.

Effect of neonatal periventricular haemorrhage on neurodevelopmental outcome. Unable to process the form.

Intrauterine hypoxia Infant respiratory distress syndrome Transient tachypnea of the newborn Meconium aspiration syndrome pleural disease Pneumothorax Pneumomediastinum Wilson—Mikity syndrome Bronchopulmonary dysplasia.